@cristian-adam that link looks very promising. It looks like there are a few variations on the proposed solution -- any idea which one I should use?
I'm running on Windows 11.
EDIT:
Problem solved.
set NODE_EXTRA_CA_CERTS=C:\ProgramData\Netskope\stagent\data\rootcaCert.cer
Or perform the equivalent from the Windows app to set environment variables.
The standard installation of Netskope only seems to include files in .pem.enc format, so my IT guy had to give me the .cer file. But...it works!
Thanks to all who looked.