I have the same problem

:-1: error: Cannot find application binary in build dir .../build-ICS_MedicalDemo-Android_Qt_5_15_13_Clang_Multi_Abi-Debug/android-build//libs/x86_64/libICS_MedicalDemo_x86_64.so. What could be the issue in this case ? I have already set ANDROID_ABI to correct x86_64 setting. 

@morteza-ali-ahmadi I'm not an Android expert. Maybe somebody else knows more.

I can open this port by:

So, as I said, the problem is not in O_LARGEFILE.

There are just a few codes in QSP sources in github link

This is not a sources, the sources is in.